Articles
  • Topic: State of the Art in the Management of Oral Squamous Cell Carcinoma

    State of the art in the management of oral squamous cell carcinoma

    Raúl González-García
    The present editorial is an introductory paper to a special issue composed of eleven manuscripts focusing on particular aspects about the state of the art in OSCC under the light of current knowledge. While strict criteria for systematic reviewing concerning Cochrane database recommendations have not been followed due to the heterogeneity of the revised series, an effort has been made to selectively approach particular aspects of OSCC management, while selecting the most prominent series within the last 15 years. Some of the incoming works have made a special effort in trying to include and...
    Published on: 25 May 2016
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  • Topic: State of the Art in the Management of Oral Squamous Cell Carcinoma

    The role of human papillomavirus in oral squamous cell carcinoma

    Francisco A. Ramírez-Pérez
    Aim: The causative role of human papillomavirus (HPV) has been established into the aetiology of oral squamous cell carcinoma (OSCC). Some authors believe that HPV can determinate the prognosis and module treatment response from this kind of malignancies. Methods: Articles published in the last 10 years, focusing on the role of HPV in the development, molecular biology, prognosis and treatment of OSCC were reviewed. Results: Thirty-nine articles from 252 were selected, highlighting 4 meta-analysis, 3 prospective and 2 retrospective studies. According to its role in the development of...
    Published on: 25 May 2016
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  • Topic: State of the Art in the Management of Oral Squamous Cell Carcinoma

    The role of sentinel node biopsy in oral squamous cell carcinoma

    Justo Serrano-Vicente
    Aim: The purpose of this study was to conduct a systematic review of the published literature to assess the state of the art of this procedure. Sentinel node biopsy (SNB) in oral squamous cell cancer (OSCC) is a novel and proven useful technique alternative to the neck dissection (ND) in the management of OSCC. Methods: The authors searched PubMed for literature in English published for the last five years, addressing this topic. Prospective studies articles were selected with at least thirty patients studied. Results: Of 235 studies found, 14 studies met the exclusion and inclusion...
    Published on: 25 May 2016
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  • Topic: State of the Art in the Management of Oral Squamous Cell Carcinoma

    The tissue shrinkage phenomenon on surgical margins in oral and oropharyngeal squamous cell carcinoma

    David González-Ballester
    Aim: One of the most important factors associated with recurrence rate and overall survival is the status of surgical margin of resection free of disease. However, sometimes, the margins measured intra-operatively at the time of surgery differ of those measured by the pathologist in the histopathologic analysis. Faced with this dilemma, a literature review of the best available evidence was conducted in an attempt to determine how the phenomenon of tissue shrinkage may influence on the surgical margin of resection in patients undergoing oral and oropharyngeal squamous cell carcinoma (SCC)....
    Published on: 25 May 2016
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  • Topic: State of the Art in the Management of Oral Squamous Cell Carcinoma

    The role of radiotherapy in the treatment of oral cavity cancer

    Joaquín J. Cabrera-Rodríguez
    Radiotherapy plays a critical role in the treatment of oral cavity squamous cell carcinoma as monotherapy in early stage cancer or combined with surgery and/or chemotherapy in advances ones. Recent developments in the imaging of cancer and radiation technology have allowed developing more precise delivery of treatment with recent data demonstrating improvement in survival and lessening of adverse toxics effects of radiation. This review will focus in the recent advances and current state-of-the-art in radiation oncology both external beam radiotherapy and brachytherapy. As complexity of...
    Published on: 25 May 2016
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  • Topic: State of the Art in the Management of Oral Squamous Cell Carcinoma

    Elective neck dissection in early oral squamous cell carcinoma: necessary?

    Carlos Moreno-García
    Aim: The indication of neck dissection in oral squamous cell carcinoma (OSCC) is a problem of risk-benefit evaluation between probability of neck metastases, the problem of complications associated with neck dissection and the prognostic influence of delayed diagnosis of metastasis during follow-up. There is no consensus on the elective treatment of the neck in early oral cancer patients with a clinically N0 (cN0) neck. Methods: The author performed a search of PubMed articles with the words "elective neck dissection vs. observation", "node negative neck" and "early stage oral squamous cell...
    Published on: 25 May 2016
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