- Dr. Ayyaz M. Shah
- Global Aesthetic Laser Academy & Shah Dermatology, University of Central Florida College of Medicine, Orlando, Florida, USA.
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Special Issue Introduction
The number one skin condition encountered by Dermatologists worldwide is the disorder of hyperpigmentation. Hyperpigmentation is defined as excess pigmentation which manifests as darker skin than the patient's normal baseline skin color. Hyperpigmentation may result from various underlying etiologies such as acne, drugs, hormonal imbalance, oral contraceptives, sun damage, enviornment, pollution, systemic illness and more.
Hyperpigmentation is a very difficult therapeutic challenge for the practicing clinician as most treatments do not produce significant or desirable skin whitening. Many patients go from doctor to doctor looking for the best hypopigmenting agent for their hyperpigmentation.
Our aim is to introduce the pathophysiology of hyperpigmentation by showing the melanogenesis (melanin synthesis) cascade. If the clinician understands the melanogenesis pathway in detail, he/she will be able to intervene at key steps with the appropriate treatments. There are many different treatment options at various steps in the pigmentary cascade which will allow the clinician to offer superior treatments in order to have more satisfied patients.
The role of topical agents, oral and topical antioxidants as well as the role of Glutathione as it pertains to skin color.
At the conclusion of this article, the reader should be much better prepared and understand the steps necessary to incorporate a successful strategy to treat patients with hyperpigmentation.
KeywordsHyperpigmentation, skin whitening, hypopigmenting agent, melasma, post-inflammatory hyperpigmentation, melanogenesis, glutathione, antioxidants, hydroquinone, tretinoin
Submission Deadline30 Sep 2018