- Prof. Raymund E. Horch
Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuernberg FAU, Erlangen, Germany. Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuernberg FAU, Erlangen, Germany.
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- Dr. Kenji Hayashida
Division of Plastic and Reconstructive Surgery, Shimane University, Shimane, Japan.
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Special Issue Introduction
Major risk factors for intractable wounds include gender, age, genetic predisposition, immunological responses of the patient, type of injury, wound size and depth, anatomical site, and mechanical tension on the wound. These factors inhibit the normal process of wound healing. Currently, with the advent of genetic engineering and advances in biological technology, there are many growth factors and stem cells known to exert powerful effects on intractable wounds. In addition to these advances, cytokine and growth factor expression profiles may be altered by physical forces, such as topical negative pressure wound treatment, which has been shown to promote wound healing by modulation of cytokines to an anti-inflammatory profile, and chemoreceptor-mediated cell as well as mechanoreceptor signaling. In vivo and in vitro studies analyzing non-healing acute and chronic wounds have demonstrated de-regulation of several growth factors (e.g., fibroblast growth factor (FGF), suggesting a potential target for therapy, which has led to robust interest in using exogenous growth factors and stem cells in the clinical setting to improve the outcomes of non-healing wounds.
The purpose of this special issue is to outline the use of growth factors and stem cells for intractable wounds and expand the knowledge of outstanding researchers all over the world. In this special issue, we hope that caregivers will be able to learn the latest topics of growth factors and stem cells for wound healing and get a bird’s eye view of comprehensive care for intractable wounds.
Wound, growth factors, stem cells, chronic wounds, intractable wounds, radiation injury, pressure ulcer, artificial dermis
Submission Deadline31 Aug 2022