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Figure 1. EVs Biogenesis, components, and cell-derived EVs solation method. (A) Biogenesis of Extracellular vehicles (EVs); (B) components of EVs; (C) Common EVs isolation steps using a serial centrifuge and sEVs isolation by either UC or SEC method prior to TEM analysis of sEVs morphology. MHC: Major histocompatibility complex; CM: condition media; ApoBDs: Apoptotic bodies; MVs: Multivesicular body; SEC: Size Exclusion Chromatography; UC: ultracentrifugation.