fig6

Figure 6. Two methods of sorting apical and basolateral proteins into the same EV. The left side depicts the progressive loss of polarity during CRC progression, leading to apical (DPEP1) and basolateral (EGFR) cell-surface proteins being in the same EV. The right side depicts different routes of trafficking of apical and basolateral proteins, which can lead to their presence in the common recycling endosome^[104]. This endosome can then mature into an MVB, which would contain both DPEP1 and EGFR in the same intraluminal vesicle.