fig6

Figure 6. Edafence^® attenuates natural aging in human primary keratinocytes as assessed by telomeric length. Primary human keratinocytes were subject to in vitro aging (24 days) under indicated conditions with and without Edafence^® treatment, 0.9 mg/mL, and processed for in situ hybridization [fluorescence in situ hybridization (FISH)] with a fluorescent probe targeting telomeric repeats (Telom. FISH, red signal; 4,6-diamidino-2-phenylindole counterstain, blue signal). Telomeric signal, as a proxy of telomere integrity/length, was acquired on a fluorescence microscope and computed as indicated. Scale bar: 10 µm. **P < 0.01. Adapted from^[86]