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Plast Aesthet Res 2021;8:[Accepted].10.20517/2347-9264.2021.46@The Author(s) 2021
Accepted Manuscript
Open AccessOriginal Article

A personalized nutrition plan based on genetic profile improves outcomes of facial regeneration with Platelet-Rich Fibrin liquid matrixes

Correspondence Address: Prof. Cleopatra Nacopoulos, Facial aesthetics and Dental Clinic, 103, Kifissias Ave, Athens 11527, Greece.


© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (, which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.


Aim: The importance of nutrition in the prevention of skin ageing has been shown by large observational studies. Despite this fact, there are no studies assessing dietary changes as adjunct procedures to aesthetic interventions. The objective of this manuscript is to study whether a personalized nutritional plan conveys additional benefits to Platelet-Rich Fibrin (PRF) facial regeneration.


Methods: Forty seven healthy women (mean age 52.5years old, SD = 7.7) were offered minimally invasive facial regeneration with the use of PRF liquid matrixes, as well as a personalized nutritional plan. The nutritional plan was informed by a nutrigenetic test based on 128 polymorphisms. Horizontal forehead lines, zygomatic wrinkles or mid-cheek furrows, nasolabial folds, perioral expression wrinkles, and marionette line were assessed separately with the use of the Facial Wrinkles Assessment Scale (FWAS).


Results: Total FWAS scores change was statistically significantly better in women who reported an at least partially adaptation of nutritional recommendations for a 3-month period or longer (z = 2.4, P = 0.008).


Conclusion: Personalized nutritional recommendations based on individual needs as well as on generally accepted dietary guidelines can improve treatment outcomes of minimally invasive facial skin aesthetics interventions.

Cite This Article

Nacopoulos C, Vlastos I, Vesala AM, Lazou E, Chaniotis D, Gkouskou K. A personalized nutrition plan based on genetic profile improves outcomes of facial regeneration with Platelet-Rich Fibrin liquid matrixe. Plast Aesthet Res 2021;8:[Accept].

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