Topic: Current Concepts in Wound Healing

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A special issue of Plastic and Aesthetic Research  (Print ISSN:2347-9264; Online ISSN:2349-6150).

Deadline for manuscript submissions: 2 May 2015

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Guest Editor(s)

  • Dr. Pramod Kumar
    Department of Plastic Surgery, King Fahad Central Hospital, Jazan 82666, Saudi Arabia.


Special Issue Introduction:

Present issue focuses on conceptual pragmatism in wound healing to bring changes in our understanding of the wound-healing process in common clinical practice, both diagnostically and therapeutically. The topics selected for this issue are about basic understanding of wound healing and new simple economic effective therapeutic method of Negative Pressure Wound Therapy within reach of poorest poor patients suffering from a variety of wounds. This issue includes the assessment of the composition of a general wound, in terms of all identifiable categories of tissue and pigmentation in an attempt to improve accuracy in assessing and monitoring wound health. Multi drug resistant (MDR) bacteria are a major problem in management of large wounds. An insight in new method of treatment of MDR infection by least harmful NPWT method has also been included. Also, less commonly discussed topic like “the effect the pH on the surface of chronic wounds healing” has been included.


Wound healing, wound surface pH, limited access dressing, NPWT, wound color-image processing, histological state of wound healing, angiogenesis, physiology of wound healing

Submission Information:

For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 2 May 2015
Contacts: Smart Zhang, Managing Editor,

Published Articles Download All Articles
  • Limited access dressing and wound infection

    Pramod Kumar
    Plast Aesthet Res 2015;2:237-8. | doi:10.4103/2347-9264.158856
    Published on: 15 Sep 2015  | Viewed:2313  | Downloaded:95
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  • Assessment of the histological state of the healing wound

    Akriti Gupta , Pramod Kumar
    The dynamic process of wound healing has various phases, and the knowledge of which is essential for identification of the pathology involved in a chronic intractable wound. Various instruments for the assessment of wound healing have been described, primarily for clinical assessment of the wound. However, very few instruments are currently available for histological grading of the wound. The aim of this article is to review all available literature from 1993 to 2014 on the objective histological scoring of the state of wound healing. This review article emphasizes the importance of... Read more
    Plast Aesthet Res 2015;2:239-42. | doi:10.4103/2347-9264.158862
    Published on: 15 Sep 2015  | Viewed:33145  | Downloaded:1411
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  • Role of angiogenesis and angiogenic factors in acute and chronic wound healing

    Thittamaranahalli Muguregowda Honnegowda , Pramod Kumar , Echalasara Govindarama Padmanabha Udupa , Sudesh Kumar , Udaya Kumar , Pragna Rao
    Angiogenesis plays a crucial role in wound healing by forming new blood vessels from preexisting vessels by invading the wound clot and organizing into a microvascular network throughout the granulation tissue. This dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix environment. Vascular endothelial growth factor, angiopoietin, fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound angiogenesis. Specific endothelial cell ECM receptors are critical for morphogenetic changes in blood... Read more
    Plast Aesthet Res 2015;2:243-9. | doi:10.4103/2347-9264.165438
    Published on: 15 Sep 2015  | Viewed:9575  | Downloaded:407
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  • Current concepts in the physiology of adult wound healing

    Friji Meethale Thiruvoth , Devi Prasad Mohapatra , Dinesh Kumar Sivakumar , Ravi Kumar Chittoria , Vijayaraghavan Nandhagopal
    Wound healing requires a complex interaction and coordination of different cells and molecules. Any alteration in these highly coordinated events can lead to either delayed or excessive healing. This review provides an overview of adult wound healing physiology. A review of the literature focused on wound healing physiology and current advances in wound healing was conducted using the online MEDLINE/PubMed database. The aim of this review was to inspire further investigation into wound healing physiology that will ultimately translate into improved patient care. Read more
    Plast Aesthet Res 2015;2:250-6. | doi:10.4103/2347-9264.158851
    Published on: 15 Sep 2015  | Viewed:114193  | Downloaded:869
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  • Effect of limited access dressing on surface pH of chronic wounds

    Pramod Kumar , Thittamaranahalli Muguregowda Honnegowda
    Aim: Changes in the pH of chronic wounds can inhibit the optimal activity of various enzymes in the wound environment, thereby delaying wound healing. The aim of the present study is to monitor the effect of limited access dressing (LAD) on the pH on the surface of chronic wounds. Methods: A total of 140 patients with chronic wounds of more than 4 weeks duration were divided into two groups by simple randomization: a LAD group (n = 64) and a conventional dressing group (n = 76). Fifty‑six participants (22 in the LAD group and 34 in the conventional dressing group) were lost to follow‑up or... Read more
    Plast Aesthet Res 2015;2:257-60. | doi:10.4103/2347-9264.165449
    Published on: 15 Sep 2015  | Viewed:4448  | Downloaded:160
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  • Computer assessment of the composition of a generic wound by image processing

    Rohit Nayak , Pramod Kumar , Ramesh R. Galigekere
    Aim: This paper addresses the assessment of the composition of a general wound, in terms of all identifiable categories of tissue and pigmentation in an attempt to improve accuracy in assessing and monitoring wound health. Materials and Methods: A knowledgebase of clusters was built into the hue, saturation and intensity (HSI) color space and then used for assessing wound composition. Based on the observation that the clusters are fairly distinct, two different algorithms, that is, Mahalanobis distance (MD) based and the rotated coordinate system (RCS) method, were used for classification.... Read more
    Plast Aesthet Res 2015;2:261-5. | doi:10.4103/2347-9264.165444
    Published on: 15 Sep 2015  | Viewed:5653  | Downloaded:114
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  • A comparative study to evaluate the effect of limited access dressing on diabetic ulcers

    Thittamaranahalli Muguregowda Honnegowda , Pramod Kumar , Krishnananda Prabhu , Ashwini Kumar , Pragna Rao , E. G. Padmanabha Udupa , Shobha Kamath , Antony Sylvan D’ Souza , Krishna Kishore Mahato
    Aim: Emerging evidence favors the important role of antioxidants, matrix metalloproteinases (MMPs), and nitric oxide (NO) in the healing of diabetic wounds. There is a lack of substantial evidence regarding the effects of negative pressure on antioxidants, MMPs and NO in chronic wounds associated with diabetes. Methods: A total of 55 type 2 diabetic patients with leg ulcers were divided into 2 groups: a limited access dressing (LAD) group (n = 27) and a conventional dressing group (n = 28). Levels of hydroxyproline, total protein, MMP‑2 and MMP‑9, NO and antioxidants including reduced... Read more
    Plast Aesthet Res 2015;2:266-71. | doi:10.4103/2347-9264.165448
    Published on: 15 Sep 2015  | Viewed:3153  | Downloaded:99
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  • Histopathological study of chronic wounds modulated by intermittent negative pressure therapy under limited access dressing

    Thittamaranahalli Muguregowda Honnegowda , Pramod Kumar , Rekha Singh , Swarna Shivakumar , Pragna Rao , Hemanth K. Prasad , Sudesh Kumar , Udaya Kumar , Echalasara Govindarama Padmanabha Udupa
    Aim: Negative pressure wound therapy (NPWT) has achieved widespread success in the treatment of chronic wounds. However, its effects have been only partially explored, and investigations have generally concentrated on the wound-dressing interface; a detailed histopathological description of the evolution of wounds under NPWT is still lacking. The present study was performed to investigate the effect of a limited access dressing (LAD) which exerts intermittent NPWT in a moist environment on chronic wounds. Methods: A total of 140 patients were randomized into 2 groups: LAD group (n = 64) and... Read more
    Plast Aesthet Res 2015;2:272-6. | doi:10.4103/2347-9264.156993
    Published on: 15 Sep 2015  | Viewed:3274  | Downloaded:90
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  • Role of jet force technology in wound management

    Vijayaraghavan Nandhagopal , Ravi Kumar Chittoria , Devi Prasad Mohapatra , Friji Meethale Thiruvoth , Dinesh Kumar Shivakumar , Arjun Ashokan
    Aim: The aim was to study the role of jet force technology (JFT) in wound management. Methods: This is a retrospective analysis of 18 cases of chronic nonhealing wounds in which JFT was used. Chronic wounds which had already undergone surgical debridement but which were not ready for reconstruction (skin graft/flap) secondary to a persistent bacterial load or infection (tissue culture positive) were included in the study. Patients were divided into two groups. Group 1 included those patients who were poor candidates for anesthesia or who refused for reconstruction and were managed with JFT... Read more
    Plast Aesthet Res 2015;2:277-81. | doi:10.4103/2347-9264.165441
    Published on: 15 Sep 2015  | Viewed:3978  | Downloaded:178
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  • Acellular micronized extracellular matrix and occlusive dressings for open fingertip injuries

    Stephanie E. Dreifuss , Ronit Wollstein , Stephen F. Badylak , Peter J. Rubin
    Plast Aesthet Res 2015;2:282-3. | doi:10.4103/2347-9264.156994
    Published on: 15 Sep 2015  | Viewed:2325  | Downloaded:125
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  • Corticosteroid - an uncertainty in management of sepsis

    Kanica Yashi
    Plast Aesthet Res 2015;2:284-5. | doi:10.4103/2347-9264.165442
    Published on: 15 Sep 2015  | Viewed:2433  | Downloaded:85
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Plastic and Aesthetic Research ISSN 2349-6150 (Online), ISSN 2347-9264 (Print)
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